The human skin replacement that got experts buzzing

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        #News(General) [ via IoTGroup ]


        An enormously elastic protein that has numerous useful medical applications – from treating acne scars, stretch marks and burns to healing surgical wounds, fixing broken arteries and coating prosthetic implants – will soon be available to patients in numerous countries.
        Elastagen, a spin-off company created by University of Sydney scientists who perfected the technique for industrially producing the protein, was sold to major global biopharmaceutical firm Allergan for $360 million last year.
        It is one of the biggest success stories so far of the NSW government’s Medical Devices Fund (MDF), which has provided $6 million of support to develop and commercialise this technology since 2013.
        The technologies developed by Elastagen are based around a molecule called elastin, which accounts for the elastic properties of many of the body’s tissues, such as the intestines, heart and bladder.
        “Anywhere in the body you need to stretch and recoil, you have elastin,” says Elastagen CEO Robert Daniels.
        “It’s quite a remarkable protein because it’s rather like nature has produced an elastic band.”
        While elastin is produced in greatest quantities during foetal development, it may also play a role in repairing adult tissues, “so if you use elastin materials in the right way, then you can repair or regenerate tissues such as skin, or blood vessels,” he adds.
        Instead, during the 1990s, a team led by Professor Anthony Weiss, University of Sydney McCaughey Chair in Biochemistry, developed a technique to use microbial cells to produce large quantities of a precursor of elastin called tropoelastin.
        The initial focus of the company was on the development of injectable gels of recombinant tropoelastin to repair skin structures such as acne scars, stretch marks and to treat wounds, as well as applications in cosmetic surgery.
        “Tropoelastin supports a natural wound-healing process that enables the skin to repair and reduces the appearance or development of the scarring,” Daniels says.


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